We previously reported a novel mouse model of calcific aortic valve stenosis by direct wire injury. Please refer to the following link.
A spring wire for angioplasty (0.36-mm diameter) bent at a 15-degree angle, was introduced into the artery.
* We used hydrophobic guide wire miracle 6 (Tip load 6 gf, ASAHI INTECH, Aichi, Japan).
* Stiff typed spring (not plastic) wire is recommended for this operation.
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